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Crepitus (grinding or clicking sensations) during movement is common

the 23 March 2026 Pfizer/Valneva VLA15 (PF-07307405) Phase 3 VALOR readout (73.2% efficacy)

This "builds over time" narrative is community-reported and aligns loosely with the synaptogenesis framing, but it is anecdote layered on a mechanism story whose foundational papers were retracted