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Although this is usually not an issue, sometimes human antibodies are immunogenic in rodents and elicit an anti-drug antibody (ADA) response

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303 Moreover, hepatic iron accumulation can induce the transcription expression of ACSL4 by activating the transcription factor c-Myc, and further aggravate the development of MASH through ferroptosis

Blockade of complex III with stigmatellin [424] and, with a slightly lower effect, also myxothiazol [425] leads to reduction of cytosolic mtROS production by complex III