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The effects of hyaluronan on proliferation of these fibroblasts was found to involve differential effects on membrane polarization, where high molecular weight hyaluronan results in depolarization and low molecular weight hyaluronan causes membrane hyperpolarization and inhibits proliferation

CNS Drugs 34:827839 Eap CB, Buclin T, Baumann P (2002) Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence