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Statistical analysis Analysis of variance (ANOVA) was conducted using the Statistical Analysis System (SAS version 9.3) (SAS Institute Inc., Cary, NC)

DAPI-stained nuclei with blue fluorescence were viewed under laser confocal microscope (LSM 510

Timing is individualized

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In ARPE-19 [human diploid retinal pigment epithelium (RPE)] cells, indomethacin or bromfenac induced the translocation of Nrf2 into the nucleus and high levels of HO-1 in the perinuclear lesion and cytoplasm