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manipulated extracellular matrix remodeling thereby increased vessel compliance to alleviate arterial stiffness through suppressing MMP2, MMP9 and TGF-, inactivated energy sensor AMPK1 to block energy supply, relived ROS overeaccumulation mediated mitochondrial dysfunction, restrained cell pyroptosis to alleviate vascular inflammation in PVR by the inhibition of HSP47, NLRP3, caspase 1, IL-1 and IL-18

doi: 10.1111/ele.12901

doi: 10.1038/s41418-021-00814-y 61

Injectable routes typically provide more consistent systemic exposure and may be preferred for non-gastrointestinal applications requiring tissue delivery beyond the digestive tract

summarizes the characterization techniques, delivery systems, and key outcomes of various drugs encapsulated in PLGA nanoparticles for PD treatment Dopamine and its precursors Monge-Fuentes et al