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In addition, continuous treatment of TQ (20 mg/kg/day, intraperitoneally, for 42 days) ameliorated D-Gal/AlCl 3 -induced cognitive deficit by protecting against oxidative stress, enhancing cholinergic function and increasing brain-derived neurotrophic factor (BDNF) and Bcl-2 levels [55]

Liver biopsies were performed on 48 patients at baseline, with 41.7% showing significant liver necroinflammation and/or fibrosis ( G2 and/or S2)

Clin Chim Acta (1971) 31(1):1923

However, this increase provides a mechanism to deliver deupleted water to the mitochondria, which may be a beneficial aspect to compensate for insufficient synthesis of metabolic water by the ATPase pumps, due to deuterium overload