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(2024) 76:e12992

How Long Do Whitening Treatments Last

Although oral therapy with the least toxic of these compounds, glutathione monoethyl ester, did raise erythrocyte and white blood cell glutathione levels in a few affected patients (W Rhead, unpublished results), it also provoked moderate gastrointestinal irritation resulting in vomiting and diarrhea, largely precluding oral therapy with this compound or other related molecules containing free sulfhydryls

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

Earlier studies demonstrated that GSH depletion could induce apoptosis 19,20 or necrosis 21 in RPE cells