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Translating an IP-injected mouse model to an oral human formulation introduced a pharmacokinetic gap that the trial design could not bridge

These medications can be helpful for some patients because they reduce abnormal nerve firing and may lessen pain attacks

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The I-kappaB kinase (IKK) family activates NF-B, which then translocates to the nucleus, where it promotes gene expression

There's also intriguing data on the nervous system -- BPC-157 has shown neuroprotective effects in animal models of traumatic brain injury and spinal cord damage, and some research suggests it modulates dopamine and serotonin pathways in ways that could affect mood and addiction