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DNA vaccines encoding HSP90 reduce lupus manifestations and prolong survival in lupus-prone mice by inducing tolerogenic dendritic cells and expanding regulatory T cells (Tregs), thereby suppressing autoimmune responses

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When the antioxidant system is reduced or imbalanced, a large accumulation of lipid peroxides occurs, thereby driving the occurrence of ferroptosis

In addition, electronic scanning microscopy assays showed that the size of adipocytes in WAT of PPT-treated mice was reduced compared to that of the DIO mice (Fig