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GPX4, using GSH as a cofactor, reduces cytotoxic lipid hydroperoxides (L-OOH) to benign lipid alcohols (L-OH) ( - transporter (a heterodimer of SLC7A11 and SLC3A2) ( 2 ), a potent lipophilic antioxidant that halts lipid peroxidation chain reactions ( Figure 2 )

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