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Homocysteine Homocysteine is a metabolite of one-carbon metabolism that is remethylated by MeCbl-dependent MS or betaine-homocysteine methyltransferase as part of the methionine cycle (Finkelstein and Martin, 1984) and degraded by cystathionine -synthase (CBS) in the transsulfuration pathway (Figure 2)

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In fact, the dose of B6 that was proposed to increase risk of cancer in this study is close to the tolerable upper intake levels set in Europe for the maximum allowed dose in over-the-counter supplements (25mg per day)