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The FDA label includes a warning that tirzepatide may reduce the effectiveness of oral hormonal contraceptives due to delayed gastric emptying

J Transl Med 13:326

This compound not only improves ventricular contractile function, but also enhances myocardial salvage and provides protection against I/R injury [27]

A meta-analysis of randomized, controlled trials demonstrated an approximately 2-fold increase in hospitalizations for heart failure among non-selective and COX-2 selective-treated patients compared to placebo (5)