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More and more researchers began to study the antioxidant effects of natural products on DCD, and a multitude of experiments were conducted in vivo and in vitro ( Table 6 )

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Safety depends on product quality, sterility, medical history, and clinician oversight

Many angiogenic factors, such as VEGF-A, HGF, transforming growth factor (TGF) and epidermal growth factor (EGF) (Folkman, 2003), demonstrated elevated expression levels in HCC tumors (Mas et al., 2007), Moreover, these factors induce angiogenesis through a number of mechanisms, one of them is via the HGF/c-Met signaling pathway

Polyamines are involved in cell division and proliferation, regulation of gene expression for cell survival, facilitation of DNA and protein synthesis, apoptosis and oxidative stress control, angiogenesis, and cell-to-cell communication (Lenis et al., 2017)