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The DEGs with known function that are positively regulated by Cyss deprivation in an NRF2-dependent manner are stress response genes involved in endoplasmic reticulum (ER) stress response and autophagy ( DDIT4 , CREB3L4 , DDIT3 , XAF1 , NUPR1, and GADD45B ) [32,33,34,35,36], mitophagy ( MORN4 ) [37] or mitochondrial biogenesis ( TFB1M ) [38]

In these vulnerable populations, administering probiotics carries a risk of serious adverse events, most notably systemic infections

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However, these findings require further validation through large-scale studies encompassing diverse diets and countries

Efficacy and safety of Statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials