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For example, enhancing oxidative phosphorylation in microglia might promote a more quiescent, neuroprotective state, while targeted inhibition of glycolysis could reduce harmful inflammation (Barros et al., 2009

Generally, for the low-risk chemical-exposure scenarios (except Crystalline and Amorphous silica occupational scenarios), the PoDs occurred at higher concentrations than the corresponding human exposure values, whereas for all the high-risk chemical-exposure scenarios, there was a clear overlap between the PoDs and lung deposited mass (benchmark inhaled materials) or maximum plasma concentration (systemically available benchmark drugs)

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Review on Antimicrobial Resistance: Tackling Drug-Resistant Infections Globally: Final Report and Recommendations

When administered intravenously, the antioxidant reaches the bloodstream directly, maximizing its availability and effectiveness