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In pathological conditions, erythrocytes can adhere to endothelial cells, which promotes the formation of microaggregates with consequent blood flow reduction [50]

Data availability The coordinates for GSTO1 inhibitor complexes have been deposited with the PDB: C1-27 (4YQM)

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Interaction with the designed ankyrin repeat protein does not affect p53 DNA binding or the crucial MDM2 negative feedback loop but reactivates a p53-dependent transcriptional program in HeLa (HPV18-positive) and SiHa (HPV16-positive) cells, suggesting a potential therapeutic use