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Mahairas, GG

10.1056/NEJMoa025039 144

The hypomethylated status of the promoter regions of multidrug resistance 1 ( MDR1 ), glutathione-S-transferase ( GST ), O(6)-methylguanine DNA methyltransferase ( MGMT ), and urokinase-type plasminogen activator ( uPA ) genes has been proposed as the mechanism contributing to chemoresistance [145]

The studies which identify these associations, while interesting and somewhat intuitive, have come under scrutiny due to challenges in adjudication and attribution of irAEs, and immortal-time bias 6