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Moreover, the ROS activates the NF-kappaB transcriptional factor, which promotes the transcription of various genes, including those involved in the synthesis of nitric oxide and proinflammatory cytokines

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Nikolaeva S, Ansermet C, Centeno G, Pradervand S, Bize V, Mordasini D, Henry H, Koesters R, Maillard M, Bonny O, Tokonami N, Firsov D (2016) Nephron-specific deletion of circadian clock gene bmal1 alters the plasma and renal metabolome and impairs drug disposition

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In particular, our study showed that the intracellular depletion of GSH is able to induce cellular stress in NO-producing cells through a NO-dependent mechanism, such as inhibition of CcOX activity, DNA damage, and S-NO and 3-nitrotyrosine (NO 2 -Tyr) protein accumulation ( Figure 1 )