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The influence of patient comorbidities (e.g., pre-existing CKD, diabetes, and hypertension)key risk factors for CINis also underexplored

Piperine Piperine has reported for protective effects in cigarette smoke (CS)-induced COPD models, probable treatment through inhibition of neutrophil and macrophage recruitments into lung tissue and inhibition of excessive production of pro-inflammatory mediators, including IL-8, LTB4, TNF-, IL-1, and ROS in the airways (Arora et al