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Finally, in the context of an adult demyelination model, leucovorin and dyclonine also improve lesion repair by promoting in parallel a microglia-mediated myelin debris clearance, and a faster transition from pro-inflammatory to pro-regenerative microglial profiles

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A study employing high-resolution immunocytochemistry at both light and electron microscopic levels in rodents has demonstrated that neurons efficiently uptake lactate via monocarboxylate transporter 2 (MCT2), a high-affinity transporter localized at postsynaptic densities to facilitate lactate import from astrocyte-released sources (Bergersen, 2007) and subsequently convert it to pyruvate via lactate dehydrogenase isotype 1

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3D-hUMSCs exosomes ameliorate vitiligo by simultaneously potentiating treg cells-mediated immunosuppression and suppressing oxidative stress-induced melanocyte damage