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Care 8 , e000902 (2020)

Example 8: Immunogenicity of the mRNA multi-pathogen vaccine directed to hMPV and RSV in mice [0394] The relative immunogenicity of the mRNA multi-pathogen vaccine directed to hMPV and RSV as described in Example 7 was evaluated in mice by measuring the circulating anti-RSV FD3 and anti-hMPV-F titers before and after IM injection with mRNA formulated with a lipid nanoparticle (LNP)

First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies