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A novel enzyme (the bifunctional glutathione synthetase encoded by gshF ) that possessed both -GCS and GS activities and was non-sensitive to GSH was discovered in several microorganisms, including Streptococcus agalactiae [10], Enterococcus faecalis [10], Listeria monocytogenes [11], and Streptococcus thermophiles [12]

Riethmller G, Gruber R, Schneider-Gdicke E, Schlimok G, Witte J, Raab R, et al

421 Synovial tissues from RA patients show significant upregulation of HSP27 mRNA, 424 and elevated levels of pro-inflammatory IL-6 are associated with increased IgG autoantibodies against HSP40, making HSP40 a potential marker of disease activity and progression

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In earlier intranasal studies, higher doses of PT-141 caused increases in blood pressure and were the reason trials were paused