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Some evolutionary perspectives on Alzheimers disease pathogenesis and pathology

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Notably, the IDH-mutant glioma we tested also contained quiescent AC-like glioma cells that were selectively depleted by RSL3, although effects on the metabolic signatures were different, suggesting that sensitivity to ferroptosis is mechanistically distinct in IDH-mutant gliomas, possibly related to the effects of the IDH-mutation on cellular metabolism (Karpel-Massler et al, 2017