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At a stage where the primary tumour and metastases are well established (4 weeks after orthotopic implantation), gemcitabine destroys chemo-sensitive cancer cells in the pancreas and in metastatic nodules

537,538 Electrical stimulation therapies, including transcutaneous electrical nerve stimulation (TENS) and spinal cord stimulation (SCS), have demonstrated effectiveness in reducing neuropathic pain intensity and improving quality of life

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