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Consequently, NRF2 dissociates from Keap1, escapes ubiquitination and degradation, accumulates in the cytoplasm, and ultimately translocates to the nucleus [85, 91, 92]

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Conclusion We show that the glutathione pools in hepatic cells and in the blood are quite insensitive to fluctuations in amino acid input and offer an explanation based on model predictions

The script was deposited on GitHub and made publicly available ( Statistical analysis of obtained light/heavy (L/H) ratios for each cysteine (resembling ratios of reduced to oxidized cysteine residues) was performed in Perseus