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MOTS-c vs NAD+: How Two Mitochondrial Compounds Compare and When a Clinic Uses Both MOTS-c and NAD+ both target mitochondrial function, but through different pathways

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Entacapone also exhibited anti-ferroptosis activity to alleviate IRI-induced renal damage and pathological changes in mice and erastin- or RLS3-induced lipid peroxidation and iron accumulation

At the joint microenvironment level, analyses of synovial fluid and cartilage tissue samples from OA patients, as well as studies in surgically induced such as the DMM model or chemically induced animal OA models, consistently observe clear iron metabolism abnormalities and significant iron accumulation locally in affected joints