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This term was initially introduced by Sies and Cadenas (1985)

Oligomeric -synuclein binds to F0/F1-ATP synthase causing oxidation of its -subunit and also lipid peroxidation of the mitochondrial membrane, which in combination with calcium overload, leads to the formation and opening of additional mitochondrial permeability channels and, as a consequence, cell death (Ludtmann et al., 2018)

Although promising for disrupting tumor proliferation and immune evasion, STAT3 and JAK inhibitors face significant limitations due to poor BBB penetration

NAC may also inhibit direct SARS-CoV-2 invasion into testicular cells by breaking the viral disulfide bonds essential for host cell invasion

Brajer B, Batura-Gabryel H, Nowicka A, Kuznar-Kaminska B, Szczepanik A