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The lack of ferroptosis-specific biomarkers has been a long-standing bottleneck, limiting the development of ferroptosis-targeted clinical applications

530 In a randomized controlled trial, 160 sedentary men and women over age 55 who had cognitive impairment but no dementia, and cardiovascular risk factors, undertook either aerobic exercise, a DASH diet, both, or a health education program

doi: 10.1017/S0007114509359127 125

Moreover, oxidative stress appears to provide a critical link between environmental factors such as exposure to pesticides, herbicides, and heavy metals with endogenous and genetic risk factors in the pathogenic mechanisms of neurodegeneration, particularly in Parkinsons disease (63, 608, 632)

Nuclear IGF-IR can not only bind to IGF-IR promoter DNA and promotes the transcription of itself [85], but also directly binds DNA and recruit RNA polymerase II to upregulate JUN and FAM21 expression in cancer cells [86]