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Importantly, because lysosomes tend to degrade drugs, during cell-based drug delivery, the intracellular inactivation of drugs needs to be prevented

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Subsequent metagenomics and bioinformatics analysis further indicated that Ami and Flu likely also modulated metabolic pathways, such as those involved in carbohydrate metabolism, membrane transport, and signal transduction

In contrast, passive targeting ( Figure 4B ) leverages the unique physiological and pathological features of tumours along with the inherent properties of the nanoparticle system to promote efficient accumulation at the tumour site

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