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5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase, an enzyme highly expressed in adipose tissue that regulates NAD+ metabolism and cellular energy balance

It has randomized Phase 3 human data in adults with HIV-associated lipodystrophy, where daily tesamorelin reduced visceral abdominal fat

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NAD+ (100 mg): MOTSc (10 mg)

3 Extended Administration Pharmacokinetics in DIO Mice Neelakantan et al., Biochemical Pharmacology (2024) This study reported a 28-day once-daily administration protocol of 5-Amino-1MQ in diet-induced obese mice, characterizing plasma pharmacokinetics, tissue distribution, and effects on body composition, fatty liver pathology, and circulating biomarkers