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While oral medications like PDE5 inhibitors are common treatments, they may not work for everyone

(PMID: 17352947)

Additionally, in animal models, NNMT gene knockdown has been found to improve insulin sensitivity (IS), glucose tolerance (GT), and overnight fasting glucose (OFG) levels, while also reducing lipid accumulation and triglyceride content (Kraus et al., 2014

Gray literature sources report doses in the range of 5-10mg per week

Tirzepatide occupies the middle ground Tirzepatide, a dual GIP/GLP-1 receptor agonist, showed a reporting odds ratio of 1.73, elevated but lower than semaglutide