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Journal of Bacteriology, 178 (18), 55225528

Similarly, NPY through activation of its Y1 receptor, was demonstrated to be critical for the development of allergic airway inflammation in mice [178]

No dose-escalation or maximum tolerated dose studies have been conducted, limiting understanding of safety at higher doses

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Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly related to its metabolic profile or interference in the metabolism of other xenobiotics