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While genetics play a huge role in hair loss, there are other factors that contribute to it

A landmark study by my colleague, Dr Devita Surjana (Cutis Dermatology) in 2012 showed at a dose of 500mg twice daily, nicotinamide has been shown to reduce solar keratoses by about 35% following two months of treatment

Sampaio et al., 2017, 2018)

This suggests that Scly plays a more pivotal role in regulating GPX1 and GPX4 selenoproteins in male BAT, while females may leverage hormone-dependent compensatory mechanisms and efficient BAT function to maintain thermogenic capacity and selenoprotein levels despite the loss of Scly