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erinaceus in rats suggest that mycelia enriched with 5 mg/g erinacine A at doses of up to 5 g/kg bodyweight/day are safe

It is worth noting that both CLSI and EUCAST provide guidelines which are primarily aimed to test the susceptibility of new clinical isolates against known antimicrobials, and not so much for testing novel compounds against known isolates, in a high throughput screening approach in which generally tests single concentration for primary screening and dose response testing only for confirmational screening