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Interestingly, astrocytes generated from neural progenitor cells that were isolated from post-mortem tissue from both fALS and sALS patients were similarly toxic specifically to wild-type motor neurons [34]

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Any of these warrant rechecking your calculation and potentially reducing the dose

Initially conservative measure are utilised to help with the pain and disability which include: Activity level and lifestyle can be modified An individualised physical therapy rehabilitation programme and regular non-impact exercise