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Subjects were randomized to receive oral doses of placebo for 9 weeks or either 5, 10, or 25 mg of MK-677 daily for an initial 2 weeks, followed by 25 mg of MK-677 daily for the next 7 weeks (n = 63 on MK-677 and n = 28 on placebo completed 9 weeks of therapy)

Study exclusion criteria may have selected patients at lower risk of overdose, and substantial loss to follow-up (approximately 80%) also may have biased estimates

Healthcare providers can offer guidance on the appropriate dosing schedule based on specific circumstances

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Nitrite/nitrate concentrations were calculated against a sodium nitrite standard curve and expressed in micromoles per liter [2]