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Oxidative stress is when you dont have sufficient antioxidants in the body so that free radicals start damaging our genetic material as well as our organs

Some antioxidant enzymes, like CAT, manganese SOD, glutathione, GPx, glutathione reductase, and copper-zinc superoxide dismutase, cannot work as well when Cd is present (17, 27, 52)

The resolution of these issues will lay the foundation for transforming ferroptosis/cuproptosis-targeted therapies toward a biomarker-driven precision medicine paradigm, ultimately achieving the synergistic improvement of therapeutic efficacy and safety in HNSCC patients