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After 24 h of co-culture with G/D-CuP, NIH/3T3 cells displayed well-spread morphology and high viability, as demonstrated by both 3D and 2D Calcein-AM fluorescence imaging via CLSM (Supplementary Fig

This creates a pharmacokinetic advantage: higher hippocampal exposure with lower systemic exposure reduces the risk of peripheral side effects while maintaining therapeutic receptor activation

The intensive lifestyle intervention group achieved greater weight loss (6.0% vs 3.5%) and reductions in glycated haemoglobin (HbA 1c ) as well as in all traditional CVD risk factors, except for LDL-cholesterol

Of the 119/48 total intermolecular NOEs for p53 TAD2 -FOXO4-DRI/p53 TAD2 -FOXO4 FH complexes only 19/2 NOEs could be assigned unambiguously

NCT04166773)