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These disruptions have been directly linked to the rapid rise in rates of type 2 diabetes, obesity, and cardiovascular diseases, which are now among the leading causes of mortality in the WHO South-East Asian region (Table 2)

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Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

In brief, indoleamine 2,3-dioxygenase (IDO) activity is increased during inflammation, leading to increased conversion of tryptophan to kynurenine, reducing substrate availability for serotonin synthesis