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PLoS ONE 6 , e19719 (2011)

Therefore, our studies add novel insights into a growing body of evidence implying that a combination of virus and host factors such as residual immune activation, hematopoietic dysregulation, and autoimmune phenomena could contribute to LC syndrome

C1-27 , cisplatin (1 M, dissolved in 0.9% NaCl), PD98059 (10 M), LY294002 (10 M), SP600125 (1 M) or desferoxamine mesylate (10 M) were added alone or in combination and colonies were allowed to grow for 710 days

Additionally, follow-up periods were generally short, limiting the ability to assess long-term effects

however, long-term randomized controlled evidence is lacking, and safety requires continued validation [336, 337]