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Acknowledgements The authors would like to express their gratitude to Margreet Osinga (Gelderse Vallei Hospital, Ede, the Netherlands), Annelies Botman (Spaarne Gasthuis, Haarlem, the Netherlands), Fellery de Lange (Medical Center Leeuwarden, Leeuwarden, the Netherlands), Jantine van Holten (Ikazia Hospital, Rotterdam, the Netherlands), Jankees K.H

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At spacings of four or more residues the energetics of binding are relatively stable

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Administration Methods Injections The most common and effective method, administered just under the skin