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Ethics statement The studies involving humans were approved by Institutional Review Board of Jimma University with reference number: IHRPG1/5/2021

Bahar ME, Kim HJ, Kim DR

Transmitted by the bite of a black-legged tick carrying Borrelia burgdorferi , Lyme disease is a bacterial infection that affects 476,000 people in the U.S

These botanical drug-derived metabolites (including naringin, neohesperidin, atractylenolide III, 23-acetyl alisol B, pachymic acid, and ursolic acid) elevate circulating and hepatic inosine levels by increasing the abundance of A