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Therefore, silybin exerts a crucial cardiovascular anti-inflammatory and protective effect through HIF-1-mediated metabolic reprogramming ( Silybin can exert anti-inflammatory, anti-fibrotic, and cardioprotective effects in cardiovascular diseases such as atherosclerosis, hypertension, and myocardial infarction through mechanisms such as regulating lipid metabolism, repairing the gut barrier, improving vascular dilation function, correcting myocardial energy metabolism disorders, and inhibiting inflammatory pathways ( Table 3 )

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Additionally, vitamin B12 deficiency can cause paresthesia or numbness in the limbs

When given orally, xanthophyll carotenoids, including AST, are mixed with bile acid and form micelles in the intestine, which are partially absorbed by intestinal mucosal cells [63]