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The IgG molecule is bonded by disulfide bridges inside the heavy and light chains and between heavy chains in the hinge region

Blood 139(5):666-677, 2022

Many individuals who carry excess weight develop joint issues that limit physical activity

& Suerbaum, S

Does a change in the total cellular GSSG/GSH ratio ultimately change that ratio in the ER, or does GSSG exert its effects on the ER environment indirectly, perhaps through the thioredoxin pathway, which also relies on NADPH and which is functionally linked to glutathione redox (Miller and Schmidt, 2019, Toledano et al., 2013)