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Yue SJ, Qin YF, Kang A, Tao HJ, Zhou GS, Chen YY, et al

MtDNA is especially vulnerable to stress-induced damage believed to be a result of the absence of histones in structure and limited effectiveness of repair mechanisms (Kim et al., 2015

Rocha VZ, Libby P

Nucleic Acids Res 31:37843788

Although other branch activations are also involved in RA, such as the cGAS-PI3K-Akt signaling pathway, this review will primarily focus on the cGAS-STING signaling pathway in the following sections (40, 41)