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The concerns raised in that process tend to cluster around a few themes: whether the substance can be reliably identified and characterized for purity, whether there is adequate human safety data, and whether the historical use supports the proposed compounding use

Previous studies reported a four- to fivefold increase in the risk of malignancy compared with the general population, although the absolute risk remains very low (Kandiel et al., 2005

Furthermore, neutrophil extracellular traps (NETs), observed in the tumor microenvironment of an inflammation model in mice, contribute to the activation of DTCs and promote cancer recurrence and metastasis

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