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While this idea is somewhat simplified, its intriguing His hypothesis suggests that the sudden influx of B12 can kickstart repair processes, and if there has been long-standing damage, the rapid onset of these processes might overwhelm the system, causing a temporary worsening of symptoms

Progress in neurobiology 93 , 204230, (2011)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 146.Haenen H.E., Spenkelink A., Teunissen C., Temmink J.H., Koeman J.H., van Bladeren P.J