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Daratumumab triggers CD38 + multiple myeloma cells [via antibody-dependent cellular cytotoxicity (ADCC), complement dependent cytotoxicity (CDC), and tumor-associated macrophages (TAMs)] in sensitive and drug-resistant patients, regulates the enzyme activity of CD38, reduces the level of adenosine and reduces adenosine-induced immunosuppression

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The thymus plays a central role in establishing immune tolerance, and thymic involution (shrinkage with age) has been linked to increased autoimmune risk

480 Similarly, a meta-analysis of 10 randomized controlled trials involving 13,623 patients with acute heart attack found colchicine did not protect against major adverse cardiovascular events or all-cause mortality, though it did lower the odds of hospital readmission