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The affected enzymes, ERK1/2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, are believed to play significant roles in cell growth, migration, and angiogenesis, which is the development of new blood vessels

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The "heat-sensitive" values within the heatmap represent the differences in multiple physiological parameters, i.e., hemoglobin levels, mean corpuscular volume (MCV), platelet counts, and proteinuria, measured before and after the administration of treatment