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J Nanosci Nanotechnol 16:261269

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Abrantes F

USP9X is a deubiquitinase that forms a multiprotein structure with the pseudokinase tribbles homolog 3 to activate Notch signaling

It is worth noting that these off-target effects may also become significant resistance factors promoting tumor progression, as targeted drugs might activate these targets to protect tumor cells [11]